Market Application & Need
Nanoparticles are being studied and used in a growing number of research and commercial applications. As part of nanoparticle synthesis and size characterization, there is a need to remove unused reactants from syntheses, purify samples through buffer exchange, and fractionate particles in a mixture according to size. Existing membrane-based solutions cannot precisely separate nanoparticles between 5 and 30 nm in size.
SepCon™ Spin Column Applications and Advantages
- Precise nanoparticle separations: separate two similarly sized nanoparticles (i.e. 5 nm from 10 nm)
- Nanoparticle synthesis clean-up: remove unused reactants to purify nanoparticle samples
- Rapid buffer exchange: order-of-magnitude faster flow rates
- Sample prep for further analysis: fractionate nanoparticles by size prior to size characterization

SepCon™ Spin Column vs. Conventional Membrane Devices
- Most nanoparticles of interest are between 5 and 30 nm in size
- 100K conventional membranes will not allow nanoparticles of 5 nm or less to pass
- 300K conventional membranes will allow 5 nm nanoparticles to pass, but will also allow 10 nm, 15 nm, 20 nm, and 30 nm nanoparticles to pass
- Only SepCon™ Spin Columns can precisely separate 5 nm from 10 nm, 10 nm from 15 nm, and 20 nm from 30 nm

SepCon™ separates 5 nm and 10 nm gold nanoparticles
To download a pdf version of the SepCon™ Spin Column Sell Sheet, click here.
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